Table 2.
Mean differences between VLNC and NNC conditions at the post-randomization Week 6 visit in cannabis users versus non-users, and p-values for tests of interactions between baseline cannabis use status and nicotine content.
| Unadjusted Modela | Adjusted Modelb | |||||
|---|---|---|---|---|---|---|
| Outcome | No Cannabis Use |
Cannabis Use | Interaction p-value |
No Cannabis Use |
Cannabis Use | Interaction p-value |
| FTND | −0.92 (−1.22, −0.62) | −0.57 (−1.00, −0.13) | 0.202 | −0.94 (−1.25, −0.64) | −0.58 (−1.01, −0.14) | 0.246 |
| QSU total score | −4.53 (−6.90, −2.15) | −9.14 (−12.56, −5.73) | 0.072 | −4.49 (−6.92, −2.07) | −8.96 (−12.49, −5.42) | 0.069 |
| QSU Factor 1 | −3.29 (−4.75, −1.84) | −5.93 (−8.10, −3.75) | 0.065 | −3.22 (−4.70, −1.73) | −5.89 (−8.12, −3.66) | 0.049 |
| QSU Factor 2 | −1.36 (−2.41, −0.31) | −3.21 (−4.73, −1.69) | 0.124 | −1.40 (−2.47, −0.32) | −3.04 (−4.62, −1.46) | 0.166 |
| MNWS | −0.61 (−1.45, 0.23) | −0.05 (−1.26, 1.16) | 0.457 | −0.74 (−1.58, 0.10) | −0.14 (−1.43, 1.14) | 0.511 |
| CESD | −0.36 (−1.81, 1.08) | 0.09 (−2.22, 2.40) | 0.732 | −0.54 (−2.01, 0.92) | 0.35 (−2.09, 2.78) | 0.564 |
| PSS | −0.22 (−0.72, 0.29) | −0.02 (−0.82, 0.78) | 0.685 | −0.22 (−0.74, 0.29) | 0.02 (−0.80, 0.83) | 0.631 |
| PANAS positive affect | −0.24 (−1.56, 1.09) | −1.85 (−3.90, 0.21) | 0.181 | −0.28 (−1.63, 1.06) | −2.25 (−4.33, −0.17) | 0.106 |
| PANAS negative affect | 0.05 (−0.96, 1.07) | −0.65 (−2.34, 1.04) | 0.512 | −0.14 (−1.14, 0.86) | −0.61 (−2.36, 1.15) | 0.559 |
| WISDM | −4.13 (−6.00, −2.26) | −0.51 (−3.38, 2.35) | 0.042 | −4.37 (−6.20, −2.53) | −0.94 (−3.84, 1.96) | 0.074 |
| CO | −0.64 (−2.07, 0.78) | −1.49 (−3.64, 0.67) | 0.377 | −0.56 (−2.01, 0.89) | −1.69 (−3.93, 0.55) | 0.298 |
| CPD | −6.08 (−7.51, −4.64) | −6.68 (−8.89, −4.48) | 0.734 | −6.19 (−7.63, −4.74) | −6.54 (−8.82, −4.26) | 0.748 |
| TNEc | −0.80 (−1.04, −0.56) | −0.61 (−1.00, −0.22) | 0.395 | −0.76 (−1.00, −0.52) | −0.61 (−1.02, −0.20) | 0.458 |
| NNALc | −0.30 (−0.46, −0.13) | −0.22 (−0.48, 0.04) | 0.641 | −0.28 (−0.45, −0.11) | −0.19 (−0.46, 0.08) | 0.560 |
| Puff count | −1.55 (−2.38, −0.73) | −0.97 (−2.44, 0.51) | 0.468 | −1.58 (−2.42, −0.73) | −1.04 (−2.6, 0.52) | 0.572 |
| Total puff volume | −107.85 (−154.73, −60.98) | −51.48 (−123.92, 20.96) | 0.250 | −97.81 (−145.25, −50.37) | −66.96 (−144.26, 10.34) | 0.574 |
| Mean puff volume | −1.12 (−4.02, 1.79) | −0.8 (−5.40, 3.81) | 0.853 | −0.57 (−3.51, 2.36) | −1.59 (−6.34, 3.16) | 0.773 |
Note: Bolded text indicates statistically significant findings p<0.05
Outcomes are expressed as differences between the VLNC and NNC conditions. Negative values indicate that those in the VLNC condition reported lower scores on a measure relative to those in the NNC condition.
Adjusted for baseline value only
Adjusted for age, race, sex, education, and NMR, along with baseline value
Findings are expressed as odds ratios - Associations between nicotine content and TNE and NNAL were summarized by the ratio of the geometric mean from the VLNC condition relative to the geometric mean from the NNC condition
Abbreviations: NNC=normal nicotine content; VLNC=very low nicotine content; CESD=Centers for Epidemiological Studies of Depression Scale; PSS=Perceived Stress Scale; PANAS=Positive and Negative Affect Scale; CPD=cigarettes per day; FTND=Fagerström Test for Nicotine Dependence; CO=carbon monoxide; QSU=Questionnaire of Smoking Urges; MNWS=Minnesota Nicotine Withdrawal Scale; WISDM=Wisconsin Inventory of Smoking Dependence Motives; TNE=total nicotine equivalents; NNAL=a biomarker of [NNK] exposure