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. Author manuscript; available in PMC: 2017 Oct 10.
Published in final edited form as: J Control Release. 2016 Aug 13;239:27–38. doi: 10.1016/j.jconrel.2016.08.013

Fig. 6.

Fig. 6

Molecular imaging and drug delivery with DNA origami nanocomposites. (A) DNA icosahedron nanostructures are loaded with pH-sensitive cargo (10-kDa fluorescein isothiocyanate – Dextran, yellow spheres) for pH mapping in C. elegans. Adapted with permission from [78]. (B) Lipid-bilayer encapsulated DNA nano-octahedron (DNO) displayed significantly enhanced blood circulation and stability. Adapted with permission from [79]. (C) DNA origami loaded with quantum dots (QDs) could be used for passive tumor targeting in vivo. Among three different structures, doxorubicin-loaded QD-Triangle DNA origami showed optimal tumor retention and remarkable drug delivery efficacy. Adapted with permission from [80].