Table 1.
Evolution of systemic and renal hemodynamics parameters during the experiment
| T0 (baseline) | T1 (shock) | T2 (30 min) | T3 (120 min) | |
|---|---|---|---|---|
| MAP (mmHg) | ||||
| Time control | 102 ± 9.0 | 86.3 ± 13.4 | 80.1 ± 8.8 | 76.8 ± 9.3 |
| Control + NAC | 87.7 ± 7.6 | 75.3 ± 10.5 | 70.5 ± 8.0 | 57.3 ± 5.6*** |
| LPS | 101 ± 11.1 | 56.8 ± 10.5*** | 53.7 ± 9.4*** | 45.8 ± 7.9*** |
| LPS + HES-RA | 92.1 ± 8.7 | 55.6 ± 9.5*** | 65.5 ± 4.9 * , + | 51.6 ± 3.7*** |
| LPS + HES-RA + NAC | 98.8 ± 8.7 | 49.8 ± 8.5*** | 64.1 ± 4.7** | 52.6 ± 6.1*** |
| RBF (ml/min) | ||||
| Time control | 5.4 ± 0.6 | 4.8 ± 0.8 | 5.3 ± 0.9 | 4.5 ± 1.5 |
| Control + NAC | 5.7 ± 0.7 | 4.3 ± 0.9 | 4.8 ± 1.5 | 4 ± 1.1 |
| LPS | 5.7 ± 1.4 | 1.3 ± 0.7*** | 1.4 ± 0.5*** | 0.7 ± 0.6*** |
| LPS + HES-RA | 6.6 ± 0.3 | 1.9 ± 1.5*** | 5.6 ± 1.8 +++ | 5.0 ± 0.4 +++ |
| LPS + HES-RA + NAC | 5.5 ± 0.4 | 1 ± 0.4*** | 3.5 ± 0.9*, ++ | 4.8 ± 2.2 +++ |
| RVR )dyn.s.sec−5) | ||||
| Time control | 1910.2 ± 260.5 | 1793.7 ± 227.4 | 1524.3 ± 188.2 | 1861.3 ± 751.2 |
| Control + NAC | 1548.6 ± 249.2 | 1782.6 ± 368.6 | 1606.7 ± 583.2 | 1521.9 ± 511.1 |
| LPS | 1774.8 ± 302.4 | 5911.5 ± 3333.4*** | 4182.9 ± 829.7* | 10,372 ± 5182.2 *** |
| LPS + HES-RA | 1410 ± 152.2 | 3293.2 ± 1978.9 + | 1130.2 ± 348.1 ++ | 1004.3 ± 48.3 +++ |
| LPS + HES-RA + NAC | 1787.2 ± 236 | 5795.8 ± 2517.4*** | 1909.8 ± 375.7 | 1199.1 ± 318.3 +++ |
LPS lipopolysaccharide, HES-RA hydroxyethyl starch-ringer acetate, NAC N-acetylcysteine
Values are presented as mean ± SD *p < 0.05, **p < 0.01, and ***p < 0.001 control versus other groups; + p < 0.05, ++ p < 0.01, and +++ p < 0.001 LPS versus other groups