Table 1.

SR-BI endogenous ligands, expression in healthy tissue, upregulation in patient derived tumor samples and expression by cancer cell lines (OxLDL, AcLDL, and LPS represent oxidized LDL, acetylated LDL and lipopolysaccharides, respectively).

Endogenous ligands	Healthy tissue	Patient tumor samples	Cancer cell lines
HDL LDL VLDL OxLDL AcLDL Lipid-free apolipoproteins (apoA-I, apoA-II, apoC-II, apoE2, apoE3, apoE4) Serum amyloid A LPS Vitamin E (Calvo et al., 1997; Xu et al., 1997; Liadaki et al., 2000; Thuahnai et al., 2003; Vishnyakova et al., 2003; Baranova et al., 2005; Reboul et al., 2006)	Liver Steroidogenic tissues (testis, ovaries, adrenals) Brain Small and large intestine Platelets (Acton et al., 1996; Husemann and Silverstein, 2001; Lobo et al., 2001; Imachi et al., 2003)	Adrenal tumors Breast cancer Lymphoma Nasopharyngeal carcinoma Pancreatic cancer Prostate cancer Prostate bone metastasis Testicular cancer (Imachi et al., 1999; Arenas et al., 2004; Cao et al., 2004; Thysell et al., 2010; Yang et al., 2013; Zheng et al., 2013; Schorghofer et al., 2015; Julovi et al., 2016; Yuan et al., 2016)	Adrenocortical: NCI-H295R Brain: SK-N-MC, MC-IXC, SK-KN-DW, 1321N1, U87 Breast: MDA-231, MDA (MB) 231, MCF7, P-148, Bone, 361, T4TD, T470, SK-Br-3 Colorectal: RKO, SWA480, SW620, HCT116, IGROV Epithelial: KB Ovarian: HIO-160, HeyA8, HeyA8-MDR, SKOV3ip1, OV 1063 Leukemia: THP-1,MT2, NB4, NB4 0076/6, MT1 Liver: HepG2, HUH-7, HF1 Lung: A549 Lymphoma: LY3, SUDHL-4, SUDHL-6, Farage, Ramos, Farage, Raji, Namalwa, Daudi, Jeko, HH, Hut-78 Nasopharyngeal: 6-10B, SUNE1, CNE2, CNE1, SUNE2, 5-8F, Pancreatic: Aspc1, L3-6PL, Panc48, Panc1, MIAPaCa-2, CFPAC-1 and BxPC3 Prostate: 22RVI, PC3, LnCap, DU145 Testicular: R2C (Lacko et al., 2002; Rao, 2002; Pilon et al., 2003; Wadsack et al., 2003; Cao et al., 2009; Fletcher et al., 2010; Shahzad et al., 2011; Shin et al., 2012; Yang et al., 2013; Zheng et al., 2013; Julovi et al., 2016)