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. 2016 Sep 27;7:392. doi: 10.3389/fimmu.2016.00392

Figure 4.

Figure 4

IFNγ-primed eASCs improve OA score. (A) OA score for tibia plateaus and femur condyles in the knee joint and mean at euthanasia. Results are expressed as the mean ± SEM, n = 10. (B) Osteoprotegerin (OPG) and (C) cartilage oligomeric matrix protein (COMP) concentrations were determined in sera of mice at euthanasia by specific sandwich enzyme-linked immunosorbent assay (ELISA). Results are expressed as the mean ± SEM, n = 10. (D) Proliferation of murine splenocytes in presence of different ratios of naïve or IFNγ-primed eASCs. Results are expressed as the percentage of ConA-induced proliferation of splenocytes which was assigned the value of 100% and represented as mean ± SEM for three independent biological replicates. Data were analyzed using the Kruskal–Wallis test followed by Dunn’s test for multiple comparisons in A, B, and C and using ANOVA followed by a Dunnett’s test for multiple comparisons in D. *p < 0.05 or p = 0.07 compared samples with the control; #p < 0.05 compared samples with each other.