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. 2016 Sep 27;7:337. doi: 10.3389/fphar.2016.00337

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Copyright © 2016 Liu, Wang, Zhao, Dong, Hu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination effect of DISS and TFSA on pCREB (phosphor-CREB)/CREB (cAMP response element-binding protein), BDNF, and CRTC1 expressions at the protein level as well as BDNF expression at the mRNA level in SY5Y cell (n = 18). SY5Y cells were treated with 75 μM or 150 μM DISS, 25 μM or 75 μM TFSA, or combination of DISS and TFSA for 24 h. (A,B,C) Combination effect of DISS and TFSA on pCREB/CREB, CRTC1, and BDNF expressions at the protein level. (D) Combination effect of DISS and TFSA on BDNF expression at the mRNA level. ^∗p < 0.05 and ^∗∗p < 0.01 compared with the control group. ^#p < 0.05 and ^##p < 0.01 compared with its compound alone.