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. 2016 Sep 27;10:480. doi: 10.3389/fnhum.2016.00480

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Copyright © 2016 Desmyter, Duprat, Baeken, Van Autreve, Audenaert and van Heeringen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart of the iTBS-sham-controlled cross-over protocol. Patients were randomized to two groups: group A (n = 22) received iTBS during the first week and sham in the second week and group B (n = 24) was administered sham stimulation during the first and iTBS in the second week. Stimulation parameters: 110% resting MT (rMT), 1620 pulses per session in 54 bursts of three with a train duration of 2 s and an intertrain interval of 8 s; five sessions per day during 4 days per week. Evaluations were carried out at four time-points: at baseline (T1), after the first week of stimulation (T2), after the second week of stimulation (T3) and 2 weeks after the last stimulation, i.e., 1 month after baseline (T4). iTBS, intermittent Theta Burst Stimulation; MT, Motor Threshold.