Skip to main content
. 2016 Sep 27;7:430. doi: 10.3389/fphys.2016.00430

Figure 6.

Figure 6

Association of LCN2 and LCN2R expression with conventional clinicopathological HCC parameters. An association study investigated the clinical significance of LCN2 and LCN2R in 138 patients who underwent curative resection of HCC. In conclusion, this study showed that the expression of both genes is correlated (r = 0.89; P < 0.001) and are up-regulated in HCC tissue and associated with vascular invasion status (P = 0.03) and TNM classification stage of malignant tumors (P = 0.004) that consider characteristics of the original primary tumor (T), the involved regional lymph nodes (N), and the occurrence of distant metastasis (M). In addition, the expression of both genes correlated well with tumor recurrence (P < 0.001), poor prognosis (P < 0.003), and overall survival rates (P < 0.001), suggesting that LCN2 and LCN2R expression are suitable prognostic factors and potential therapeutic targets in HCC. Details of this study are given elsewhere (Zhang et al., 2012).