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. 2016 Sep 27;8:223. doi: 10.3389/fnagi.2016.00223

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Copyright © 2016 McIntee, Giannoni, Blais, Sommer, Neubert, Rostagno and Ghiso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative analysis of Aβ species cleared to the CSF after intracerebral injection of monomeric and oligomeric Aβ1-40. MALDI-ToF spectra and normalized ion counts on CSF collected 30 min after intracerebral injection of comparable amounts of monomeric (top panel) and oligomeric (bottom panel) Aβ1-40 immunoprecipitated with anti-Aβ monoclonal antibody 6E10. For the immunoprecipitation, CSF was pooled from 4 mice injected under the same experimental conditions. Data are representative of 2 independent experiments (n = 8) spotted in duplicate in the mass spectrometer aluminum plates.

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