Table 3.
GO term enrichment of the genes with increased transcription in the spleen of mice infected with S. epidermidis biofilm-released cells.
| GO ID | Cluster representatives | N. of genes | P-value |
|---|---|---|---|
| BIOLOGICAL PROCESS | |||
| GO:2001242 | Regulation of intrinsic apoptotic signaling pathway | 11 | < 0.0001 |
| GO:2000116 | Regulation of cysteine-type endopeptidase activity | 12 | < 0.0001 |
| GO:0043409 | Negative regulation of MAPK cascade | 9 | < 0.0001 |
| GO:1903039 | Positive regulation of leukocyte cell-cell adhesion | 9 | < 0.001 |
| GO:0050870 | Positive regulation of T cell activation | 8 | 0.001 |
| GO:0044003 | Modification by symbiont of host morphology or physiology | 4 | 0.001 |
| GO:0031329 | Regulation of cellular catabolic process | 15 | 0.003 |
| GO:0010623 | Developmental programmed cell death | 4 | 0.004 |
| GO:0002260 | Lymphocyte homeostasis | 5 | 0.005 |
| GO:0031638 | Zymogen activation | 6 | 0.006 |
| GO:0006986 | Response to unfolded protein | 5 | 0.007 |
| GO:0031341 | Regulation of cell killing | 5 | 0.007 |
| GO:0010243 | Response to organonitrogen compound | 13 | 0.007 |
| GO:0032693 | Negative regulation of interleukin-10 production | 3 | 0.007 |
| GO:1901698 | Response to nitrogen compound | 14 | 0.010 |
| GO:0048646 | Anatomical structure formation involved in morphogenesis | 18 | 0.010 |
| GO:0019724 | B cell mediated immunity | 5 | 0.011 |
| GO:0035966 | Response to topologically incorrect protein | 5 | 0.011 |
| GO:0010727 | Negative regulation of hydrogen peroxide metabolic process | 2 | 0.011 |
| GO:0010743 | Regulation of macrophage derived foam cell differentiation | 3 | 0.014 |
| GO:0043243 | Positive regulation of protein complex disassembly | 3 | 0.014 |
| GO:0033043 | Regulation of organelle organization | 19 | 0.016 |
| GO:0009628 | Response to abiotic stimulus | 16 | 0.017 |
| GO:0009888 | Tissue development | 25 | 0.017 |
| GO:0033209 | Tumor necrosis factor-mediated signaling pathway | 3 | 0.020 |
| GO:0042940 | D-amino acid transport | 2 | 0.023 |
| GO:0016192 | Vesicle-mediated transport | 16 | 0.030 |
| GO:0018149 | Peptide cross-linking | 3 | 0.030 |
| GO:0045787 | Positive regulation of cell cycle | 8 | 0.030 |
| GO:0061028 | Establishment of endothelial barrier | 3 | 0.032 |
| GO:0048147 | Negative regulation of fibroblast proliferation | 3 | 0.035 |
| GO:0008637 | Apoptotic mitochondrial changes | 4 | 0.038 |
| GO:0034976 | Response to endoplasmic reticulum stress | 5 | 0.046 |
| GO:0009314 | Response to radiation | 9 | 0.046 |
| GO:0051604 | Protein maturation | 7 | 0.047 |
| GO:0051195 | Negative regulation of cofactor metabolic process | 2 | 0.048 |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | 4 | 0.048 |
| MOLECULAR PROCESS | |||
| GO:0050786 | RAGE receptor binding | 4 | < 0.001 |
| GO:0016209 | Antioxidant activity | 6 | 0.005 |
| GO:0048020 | CCR chemokine receptor binding | 4 | 0.005 |
| GO:0046983 | Protein dimerization activity | 24 | 0.016 |
| GO:0038024 | Cargo receptor activity | 5 | 0.038 |
| GO:0042803 | Protein homodimerization activity | 17 | 0.046 |
| CELLULAR COMPONENTS | |||
| GO:0031988 | Membrane-bounded vesicle | 50 | < 0.001 |
| GO:0043226 | Organelle | 108 | 0.002 |
| GO:0043227 | Membrane-bounded organelle | 116 | 0.016 |
| GO:0044424 | Intracellular part | 115 | 0.017 |
| GO:0005737 | Cytoplasm | 99 | 0.017 |
| GO:0005912 | Adherens junction | 12 | 0.018 |
| GO:0072559 | NLRP3 inflammasome complex | 2 | 0.027 |
| GO:0005622 | Intracellular | 114 | 0.032 |
| GO:0005576 | Extracellular region | 46 | 0.042 |