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. 2016 Sep 27;7:432. doi: 10.3389/fphys.2016.00432

Figure 2.

Figure 2

Neonatal maternal separation (NMS) decreases carotid sinus nerve (CSN) response to hypoxia in female rats. (A) Original recordings comparing CSN activity from ex vivo preparations of perfused carotid body/CSN from control and NMS females under hyperoxia (FiO2 = 0.95), hypoxia (FiO2 = 0.0) and hyperoxia after hypoxia (recovery). (B) Comparison of the mean carotid sinus nerve activity (imp/sec) over the course of the hypoxic protocol between carotid bodies from control (open squares; n = 5) and NMS rats (black squares; n = 5). Hypoxia begins at T = 0 and is maintained until T = 500 s (end of plateau phase), followed by hyperoxic recovery; each data point represents the mean value on a second by second basis. (C) Histograms comparing mean CSN activity for each specific experimental condition between control (white bars; n = 5) and NMS (black bars; n = 5) female rats. Data are reported as means ± SD. *Indicates a value statistically different from control at p ≤ 0.05.