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. 2016 Sep 27;7:419. doi: 10.3389/fphys.2016.00419

Figure 3.

Figure 3

Experimental measurements of PKA activity and action potential (AP) firing rate as a function of sympathetic stimulation (via adrenergic receptors, A,B) using isoproterenol (ISO) and parasympathetic stimulation (via cholinergic receptors, C,D) using carbachol (CCh) in rabbit pacemaker cell. (A,C) Show representative examples, (B,D) present average data for n = 5 and n = 4 pacemaker cells (from 5 and 4 rabbits, respectively), respectively, with the vertical bars representing the standard errors. (E) Shows the relationship between the AP firing rate and PKA activity, as obtained from the ISO and CCh measurements. Equation for the curve fitting of the AP-PKA relationship: 26.4434+90.3024·x16.9029/(0.671316.9029+x16.9029).