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. 2015 Jun 8;13(5):593–604. doi: 10.1038/cmi.2015.39

Figure 3.

Figure 3

Wnt5a negatively regulated DC differentiation. Control or Wnt5a-overexpressing plasmids were transfected into CD45.2+Lin− cells. CD45.1+ mice were lethally irradiated and reconstituted with a mixture of CD45.1+ BM cells and CD45.2+GFP+Lin− cells. (A) The overexpression of Wnt5a in Lin− cells. (B) The plots show the percentages of donor-derived DC subsets in the spleens of control and Wnt5a-overexpressing chimeric mice 4 weeks after Lin− cell transplantation. (C) The percentages and numbers of donor-derived DC subsets, and the total numbers of GFP+ donor-derived splenocytes. Data are representative of three independent experiments, each including 5–8 mice. Error bars represent SEM (*P < 0.05, **P < 0.01).