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. 2015 Jun 8;13(5):593–604. doi: 10.1038/cmi.2015.39

Figure 7.

Figure 7

Blocking of the Wnt5a-Cdc42 pathway rejuvenated the differentiation of aged DC. CD45.2+ LSK were isolated from the BM of young and aged mice treated with or without CASIN for 16 hours and transferred into lethally irradiated CD45.1+ mice. DC subsets in the spleens of chimeric mice were analyzed 16 weeks after transplantation. (A) The FACS plots show the percentages of DC subsets in the chimeric mice. (B) The graph summarizes the percentages of DC subsets in the chimeric mice. (C) The numbers of DC subsets. Data are representative of two independent experiments. Error bars represent SEM (*P < 0.05, **P < 0.01).