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. 2015 Jul 20;13(5):658–668. doi: 10.1038/cmi.2015.46

Figure 5.

Figure 5

The downstream genes of MEK2 in regulation of temozolomide sensitivity. ABCB1, ABCC1, ABCC2, ABCG2, BCL2, or MGMT mRNA expression levels in U251 (a) and U87 (b) cells with MEK2 silenced (si-MEK2) or its control group (si-ctl) as measured by real-time PCR.**P < 0.01 vs. si-ctl. The correlation coefficients of MEK2 mRNA expression and ABCG2 (c) or MGMT (d) mRNA expression in 34 human tissues (including normal brain and glioma tissues) as measured by real-time PCR. All results are expressed as the mean ± SD from at least three independent experiments.