Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 22;167(1):260–274.e22. doi: 10.1016/j.cell.2016.08.041

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Figure S4 — Related to Figure 4 and STAR Methods

(A) Representative microscopy images from 8 PDTX models of short-term cultures (PDTCs) at day 7 after plating.

(B) Box plots showing the percentage of human DNA on PDTX (n = 94 samples) and PDTC (n = 15 samples) models (n = 29). Data estimated from our sequencing-based approach.

(C) Changes in cell number and viability of PDTCs at each time-point.

(D) Representative FACS image from PKH26 assay. Table showing quantification of PKH26 low cells in 2 PDTCs (STG195 and STG201) and a highly proliferative breast cancer cell line (MDAMB231), shown for comparison purposes, at different time-points.

(E) Scatterplots comparing AUC values measuring drug response for 19 drugs in 8 models (AB521, AB555, AB582, STG195, STG316, STG321, STG335 and VHIO093) using 3 different viability assays. 10 different doses were tested. Curve fitting and computation of the AUC was done as described in the STAR Methods. Dots highlighted in color correspond to PI3K pathway inhibitors: GDC032 (PI3Kα) in red, GDC0941 (pan PI3K) in blue, AZD6482 (PI3Kβ) in purple, and AZD8055 (mTOR) in green.