Figure 8.

Photoreceptor degeneration was observed in Ikbkap CKO retinas. The number of rows of photoreceptor nuclei in the ONL was counted at 0.25 mm from the optic nerve in the temporal and nasal retinas at 6 months (A), 9 months (C), and 14 months (E). H&E-stained cross sections. A and B, At 6 months, no sign of photoreceptor degeneration was observed. C and D, At 9 months, significant loss of photoreceptors and disorganization of ONL (arrowheads) in the mutant temporal and peripheral retinas were observed. E and F, At 14 months, the number of rows of photoreceptor nuclei was clearly reduced across the retina. In addition, photoreceptor IS and OS were absent. Error bars in A, C, and E represent SEM (*p < 0.05 with t-test). Scale bars, 50 μm (B, D, and F).