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. 2016 Oct;148(4):277–291. doi: 10.1085/jgp.201611625

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© 2016 Naranjo et al.

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Figure 2. — Occupancy and dimensions of the internal cavity and the maximum conductance of Kv and BK channel. (A) Alignment of the Kv1.2/2.1 chimera (gray backbone) with MthK (blue) pore domain structures. Shown are the diagonal subunits, with front and back subunits omitted for clarity. K⁺/water in the selectivity filter are green spheres. The side chains shown on CPK color correspond to the glutamate ring equivalent positions (right for MthK and left for Kv1.2/2.1). The residues in yellow are the internal cavity residues able to tolerate aspartate substitution. Kv2.1/1.2 chimera: PDB ID 2R9R; MthK: PDB ID 4HYO. (B) Role of charged residues in the inner cavity on maximum conductance of Shaker and BK. Maximal conductance is defined as the unitary conductance at saturating K⁺ concentration.