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. 2016 Sep 27;6:33926. doi: 10.1038/srep33926

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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(A) ¹⁸F-FLT PET activity decreased in vitro in TC32 Ewing sarcoma cells with siRNA silencing of EWS-FLI1(siEWS) but not with a non-targeting control (siNeg); EWS-FLI1 suppression with mithramycin (MMA), EC-8042, or EC-8105 decreases ¹⁸F-FLT activity (B) ¹⁸F-FDG activity does not change with siRNA silencing of EWS-FLI1 and with EWS-FLI1 suppression with mithramycin (MMA), EC-8042, or EC-8105. 5FU suppresses ¹⁸F-FDG activity likely due to a loss of cell viability.