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. 2016 Sep 27;6:33951. doi: 10.1038/srep33951

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Dot-plots of correlations between (a) Plasma concentrations of C-reactive protein and 3-hydroxykynurenine, for the tAP cohort grouped by AP severity (mild AP n = 25; moderate AP n = 23; severe AP n = 9). Data points represent means; error bars show standard deviation on both axes. The dashed red line represents mean 3-hydroxykynurenine plasma concentration in healthy volunteers (n = 8). (b) APACHE II score and contemporaneous log₁₀ 3-hydroxykynurenine plasma concentrations. Due to the non-normal distribution of plasma concentrations of of 3-hydroxykynurenine, a logarithmic transformation was used for the correlation to provide a better fit. For both correlations, results from samples obtained from T0 up to and including T48 were analysed. Results of respective Spearman correlations have been appended on each figure of the panel.