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Estimated marginal means of age-corrected z-scores for clinical high risk participants who endorsed using alcohol at a ‘use without impairment’ severity level (cannabis users, n=100, and cannabis non-users, n=110) for thalamus, hippocampus and amygdala, adjusted for intracranial volume. Significantly smaller hippocampi were seen in CHR cannabis users compared to CHR non-users. Dotted line represents the approximate mean value of healthy controls.
