Table 3. Longitudinal (one year) change in T2 values in knees without ROA but with risk factors for ROA (risk ROA), in knees with early ROA, and in healthy reference knees.
| Risk ROA (N = 26) Mean ± SD (95% CI) | Early ROA (N = 24) Mean ± SD (95% CI) | Healthy (N = 89) Mean ± SD (95% CI) | Risk ROA vs. Early ROA Crude/Adjusted Cohen’s D | Risk ROA vs. Healthy Crude/Adjusted Cohen’s D | Early ROA vs. Healthy Crude/Adjusted Cohen’s D | ||
|---|---|---|---|---|---|---|---|
| Avg | Deep | 0.0 ± 1.7 | −0.2 ± 1.1 | 0.8 ± 1.3 | 0.684/0.583 | 0.010/0.032 | 0.001/0.002 |
| (−0.7, 0.7) | (−0.6, 0.3) | (0.5, 1.1) | 0.12 | 0.58 | 0.78 | ||
| Superficial | −0.4 ± 1.8 | −0.1 ± 1.5 | 0.5 ± 1.4 | 0.581/0.694 | 0.006/0.024 | 0.041/0.029 | |
| (−1.1, 0.3) | (−0.8, 0.5) | (0.2, 0.9) | 0.16 | 0.62 | 0.48 | ||
| MT | Deep | −0.3 ± 1.8 | 0.0 ± 1.6 | 0.8 ± 1.7 | 0.504/0.533 | 0.003/0.013 | 0.033/0.082 |
| (−1.1, 0.4) | (−0.7, 0.7) | (0.5, 1.2) | 0.19 | 0.67 | 0.50 | ||
| Superficial | −0.4 ± 1.8 | 0.1 ± 1.8 | 0.7 ± 1.8 | 0.323/0.358 | 0.008/0.044 | 0.175/0.202 | |
| (−1.2, 0.3) | (−0.7, 0.9) | (0.3, 1.0) | 0.28 | 0.60 | 0.31 | ||
| cMF | Deep | 0.3 ± 2.9 | −0.3 ± 2.5 | 1.0 ± 2.1 | 0.461/0.409 | 0.169/0.314 | 0.012/0.019 |
| (−0.9, 1.4) | (−1.3, 0.7) | (0.5, 1.4) | 0.21 | 0.31 | 0.59 | ||
| Superficial | −0.5 ± 4.5 | −0.5 ± 4.2 | 0.4 ± 2.6 | 0.993/0.904 | 0.195/0.219 | 0.196/0.060 | |
| (−2.3, 1.3) | (−2.3, 1.3) | (−0.1, 0.9) | 0.00 | 0.29 | 0.30 | ||
| LT | Deep | −0.1 ± 1.9 | −0.2 ± 0.9 | 0.9 ± 1.5 | 0.730/0.512 | 0.010/0.026 | 0.001/0.002 |
| (−0.9, 0.7) | (−0.6, 0.1) | (0.5, 1.2) | 0.10 | 0.58 | 0.77 | ||
| Superficial | −0.2 ± 1.8 | −0.1 ± 0.9 | 0.6 ± 1.5 | 0.872/0.937 | 0.024/0.089 | 0.025/0.041 | |
| (−0.9, 0.5) | (−0.5, 0.3) | (0.3, 0.9) | 0.05 | 0.51 | 0.52 | ||
| cLF | Deep | 0.1 ± 1.8 | −0.2 ± 1.3 | 0.6 ± 1.8 | 0.545/0.516 | 0.182/0.227 | 0.038/0.023 |
| (−0.6, 0.9) | (−0.7, 0.4) | (0.3, 1.0) | 0.17 | 0.30 | 0.48 | ||
| Superficial | −0.5 ± 1.0 | 0.0 ± 1.1 | 0.6 ± 2.1 | 0.133/0.138 | 0.020/0.056 | 0.212/0.334 | |
| (−0.9, −0.1) | (−0.5, 0.4) | (0.1, 1.0) | 0.43 | 0.52 | 0.29 |
SD = standard deviation; Avg = average values across all four femorotibial cartilage plates; MT = medial tibia; cMF = weight-bearing (central) medial femur; LT = lateral tibia; cLF = weight-bearing (central) lateral femur; for a definition of the regions of interest, please also see Fig. 1; significant change between baseline and one year follow up with p < 0.05 is marked in italics, and with p < 0.01 in bold letters.