Figure 6. Overexpression of MKP-1 protects macrophages against impaired autophagy, and accelerated cell death.

Bone marrow-derived macrophages were infected with lentiviral vectors carrying either Flag-tagged MKP-1 or GFP. Cells were then treated for 24 hours with vehicle or primed with LDL + HG, and p62 protein levels (A), Caspase-3/7 activities (B Results are shown as mean ± SE (n = 3–4).