Figure 2. Expression of IFN-α receptors in primary sensory neurons in the DRG.

(A) Double staining showing colocalization of IFN-α/βR with substance P and IB4 but not with NF200 in the DRG. Arrows indicate double-labeled neurons. Scale, 50 μm. (B) Size frequency distribution of IFN-α/βR-positive neurons in the DRG. Twelve DRG sections from 4 animals were included for quantification. Note that 26% DRG neurons express IFN-α/βR in normal conditions. Most IFN-α/βR-positive neurons have cross-sectional areas of 200–600 μm².