Table 2.
New HSF-correlated structures in the PDB database, using DELTA-Blast.
| Feature | HSF (323) | |||
|---|---|---|---|---|
| Template (PDB ID) | 4LZI | 3PS8 | 1R4C | 1G96 |
| Release date | 26 February 2014 | 21 December 2011 | 21 September 2004 | 6 April 2001 |
| Number of aligned residues | 222 | 115 | 107 | 115 |
| E-value | 4 × 10−55 | 6 × 10−35 | 8 × 10−36 | 2 × 10−34 |
| Identity | (31/222) 14% | (15/115) 13% | (17/107) 16% | (15/115) 13% |
| Positives | (67/222) 30% | (39/115) 33% | (32/107) 29% | (39/115) 33% |
| Gaps | (55/222) 24% | (8/115) 6% | (4/107) 3% | (8/115) 6% |
DELTA-Blast search followed by PSI-Blast, with the default parameters described in Table 1. Template is the best hit, identified by its PDB ID number. Release date is the structure’s publication date in the database. E-value is the expected number of chances that the match is random. Three percentages are calculated relatively to the number of aligned residues: identity (exact match residues), positives (exact + homology match residues), and gaps (inserted spaces to allow the alignment). Despite the intermediate sequential identity value, the structure 4LZI shows the best sequence coverage (number of aligned residues) and positive matches, being the best template since structure 1G96. 4LZI: Solanum tuberosum multicystatin. 3PS8: L68V mutant of human cystatin C. 1R4C: N-truncated human cystatin C, dimeric form. 1G96: human cystatin C, dimeric form.