Table 1.

In vitro anticancer effects of quercetin and its analogs.

Compound tested	Cell lines	Effects	Mechanisms	References
Quercetin	MCF-7, HCC1937, SK-Br3, 4T1, MDA-MB-231	Induced apoptosis	↑Bcl-2,↓Bax expression,↓Her-2, inhibition of PI3K-Akt pathway	[71]
Quercetin	MIA PaCa-2, BxPC-3	Inhibited proliferation	↓Her-2, regulation of Wnt/β-catenin	[72]
Quercetin	CX-1, SW480, HT-29, HCT116	Inhibited proliferation	↓HIF-1κ, regulation of Wnt/β-catenin	[73]
Quercetin	LNCaP, PC-3	Inhibited proliferation	↓VEGF secretion, ↓mRNA levels	[74]
Quercetin	HepG2	Inhibited proliferation	↓PI3K,↓PKC	[75]
Rutin	ACC	Inhibited proliferation	↓PI3K,↓Akt,↓IKK-α,↓NF-κB	[76]
Rutin	SKOV3	Inhibited cell growth	↓Cyclin D1	[77]
Rutin	HeLa	Inhibited cell growth	↑p53,↓NF-κB	[78]
Quercetin	A549	Inhibited cell growth	↓cdk1,↓cyclin B	[79]
Quercetin	JB6 P+	Inhibited cell migration	Regulation of p13K/Akt	[5]
Quercetin	U373MG	Inhibited cell migration	↑caspase-7,↑JNK,↑p53	[80]