Table 2.

In vivo anticancer effects of quercetin and its analogs.

Compound tested	Animal models	Effects	Mechanisms	Dose	Duration	References
Quercetin	FemaleCF1 mice	Retarded tumor growth	↓PCNA;↑mmu-miR-205-5P	8 g/kg/day (diet)	42 days	[88]
Quercetin	Male F344 rats	Inhibited tumor growth	↓EphA2;↓PI3K;↓MMP-2;↓MMP-9	100 mg/kg (i.p.)	18 days	[89]
Rutin	Male F344 rats	Suppressed tumor growth	↓ACF	25 mg/kg (i.p.)	28 days	[89]
Quercetin	Female CD-1 mice	Inhibited tumor nodule formation	↓papilloma	3–6 mg/kg (p.o.)	14 days	[90]
Quercetin	Male Swiss mice	Inhibited tumor nodule formation	↓AD	6 mg/kg (i.p.)	2 times/week 21 days	[91]
Quercetin	Female Sprague-Dawley rats	Reduced tumor volume	↓ADC	17.5 mg/kg (i.v.)	2 times/week for 24 days	[92]

i.p., intraperitoneal; i.v., intravenous; p.o., per os.