Effects of dietary PGE on body weight gain, plasma lipid profiles, insulin resistance, and glucose tolerance via modulating hepatic glucose-regulating enzyme activities in HFD-fed C57BL/6J mice. The data are the mean ± SEM (n = 10). (A) Changes in the body weight, food intake, and food efficiency ratio (FER); (B) levels of plasma total, HDL, and non-HDL cholesterol, AI, TG, FFA, Apo A-1, and Apo B; (C) levels of plasma resistin, leptin, TNF-α, and PAI-1; (D) blood glucose levels after 12 h of fasting; (E) plasma insulin and glucose levels after 12 h of fasting and the HOMA-IR calculated using the fasting blood glucose and insulin levels; (F) glucose tolerance; and (G) activities of the glucose-regulating enzymes G6Pase and PEPCK. ND, mice fed a normal diet; HFD, mice fed a high-fat diet (HFD) alone; PGE, Platycodon grandiflorus root extract (5%, w/w)-treated HFD-fed mice. B.W., body weight, AI, atherogenic index, ((Total-C)-(HDL-C))/HDL-C.