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The effect of 300 mg/kg acetaminophen (Apap) on brain PGE2 levels in COX-1 KO and COX-2 KO mice. Brains of COX-1 KO mice (A) and COX-2 KO mice (B) were removed and frozen 1 h after administration of acetaminophen to male or female animals. Acetaminophen reduced PGE2 in WT and KO mice except Ptgs1–/–. Control PGE2 levels in Ptgs1–/– animals were ≈30% of those in WT; n = 4–7; n.s., not significant.
