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. 2016 Sep 27;11:12. doi: 10.1186/s13008-016-0025-2

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — General view of the NSP: once a ligand of the DSL family in the signal sending cell interacts with the Notch receptor of the signal receiving cell, NICD is released by proteolysis and translocated to the nucleus activating the pathway for a positive gene regulation together with CSL proteins, Mastermind (Mam) protein and histone acetyltransferases (HATs). Otherwise NSP is repressed by “default repression” complexes structured by Hairless (H) protein and C-terminal binding protein (CtBP) and Groucho (Gro) co-repressors