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. 2016 Sep 27;11:12. doi: 10.1186/s13008-016-0025-2

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The CSL proteins: CSL proteins are transcription factors regulating the Notch pathway in a positive and negative fashion. CSL type transcription factors have three functional domains well characterized: N-terminal domain (NTD), beta-trefoil domain (BTD) and C-terminal domain (CTD) which are used for protein–protein or protein-DNA interactions