Table 1.

Major adipokines involved in nonalcoholic fatty liver disease (NAFLD) pathogenesis.

Adipokines	Function
Adiponectin	Anti-inflammatory, improve insulin sensitivity, prevent lipid accumulation, attenuate fibrosis, inhibit tumor necrosis factor (TNF-α) synthesis and/or release [36,37,38,39,40]
Leptin	Prevent lipid accumulation, amplify inflammation, induce fibrosis, increase TNF-α concentration [41,42,43,44]
TNF-α	Promote inflammation, induce lipid accumulation and insulin resistance, pro-fibrotic effect [45,46,47,48]
Resistin	Cause insulin resistance, reduce interleukin 6 (IL-6) secretion, participate in liver fibrogenesis [49,50,51,52,53]
IL-6	Suppress oxidative stress and prevent mitochondrial dysfunction [54,55,56]