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. 2016 Aug 23;17(9):1387. doi: 10.3390/ijms17091387

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of (a) E- and (b) P-cadh-associated signaling cascades activated in EOCs (Epithelial Ovarian Cancers). The arrows indicate: green, protein-protein interaction, black, signaling cascades; discontinuous, possible signaling cascade; red, cellular effects. The abbreviation used are: cadh, cadherin; IGF-1R, Insulin Growth Factor Receptor 1; ERK, Extracellular signal-Regulated Kinase; MEK, MAP or ERK kinase; PI3K, phosphoinositide 3-kinase; p120, p120 catenin. Rho, Rac and CDC42 are Rho-GTPases.