Table 4.
Oxidative stress markers after 6 months of follow-up.
| Oxidative Stress Marker | Healthy | Metabolic Syndrome | ||||||
|---|---|---|---|---|---|---|---|---|
| Hormone Therapy | Placebo | Hormone Therapy | Placebo | |||||
| Basal (n = 25) | 6 mo. (n = 23) | Basal (n = 25) | 6 mo. (n = 23) | Basal (n = 25) | 6 mo. (n = 23) | Basal (n = 25) | 6 mo. (n = 22) | |
| Lipid peroxides (µmol/L) | 0.340 ± 0.01 | 0.290 ± 0.01 a | 0.336 ± 0.01 | 0.348 ± 0.01 | 0.355 ± 0.01 | 0.282 ± 0.01 a | 0.357 ± 0.01 | 0.346 ± 0.01 |
| SOD (U/g·Hb) | 1.24 ± 0.03 | 1.26 ± 0.04 | 1.16 ± 0.02 | 1.19 ± 0.03 | 1.23 ± 0.05 | 1.26 ± 0.02 | 1.21 ± 0.03 | 1.22 ± 0.02 |
| GPx (U/g·Hb) | 53.0 ± 2.7 | 62.2 ± 2.7 b | 50.2 ± 3.0 | 52 ± 2.5 | 52.1 ± 4.8 | 62.9 ± 2.8 a | 52.5 ± 4.3 | 54.6 ± 3.2 |
| TAS (µmol/L) | 963 ± 41.5 | 1049 ± 40.4 | 1077 ± 50.7 | 1110 ± 48.2 | 1075 ± 41.8 | 1155 ± 48.3 | 1068 ± 43.2 | 1103 ± 60.0 |
| Uric acid (µmol/L) | 259 ± 15.2 | 240 ± 18.3 | 261 ± 17.3 | 275 ± 16.6 | 279 ± 21.0 | 253 ± 17.2 | 284 ± 19.4 | 300 ± 15.0 |
| SOD/GPx ratio | 0.023 ± 0.001 | 0.021 ± 0.001 | 0.025 ± 0.001 | 0.024 ± 0.001 | 0.026 ± 0.002 | 0.020 ± 0.001 a | 0.025 ± 0.002 | 0.023 ± 0.001 |
| Antioxidant gap (µmol/L) | 239 ± 40.9 | 276 ± 39.8 | 334 ± 51.0 | 357 ± 49.1 | 316 ± 52.0 | 460 ± 44.5 c | 298 ± 37.0 | 336 ± 56.1 |
Paired t-test: a p < 0.0001; b p = 0.001; c p < 0.05. SOD: superoxide dismutase; GPx: glutathione peroxidase; TAS: total antioxidant status; 6 mo.: 6 months. Data show mean ± standard error.