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Hypoxia induces IGFBP expression. (A) The altered expression of growth factors was examined using an antibody array. Hypoxia (2%, 24 h) upregulated the protein expression of IGFBP families in ASCs; (B) the mRNA level of IGFBP families under hypoxia was measured. Hypoxia significantly upregulated IGFBP3–6. Normoxia: black bars, hypoxia: white bars. ** p < 0.01.
