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. 2016 Sep 2;17(9):1427. doi: 10.3390/ijms17091427

Figure 1.

Figure 1

Effect of miR-378 on oxygen-glucose deprivation (OGD)-induced ischemic injury in N2A cells. (A) miR expression decreased in cultured N2A cells exposed to 3 h OGD following different reoxygenation times. * p < 0.05 vs. normoxia, n = 5 per group; (B) Transfection of pri-miR-378 or anti-miR-378 significantly increased or decreased the level of miR-378 in normoxia and 3 h OGD/24 h reoxygenation treatments, * p < 0.05 vs. normoxic non-trans, # p < 0.05 vs. OGD non-trans, n = 5 per group; (C,D) MTT assay showed that pri-miR-378 and anti-miR-378 transfection significantly increased or decreased cell survival, respectively, following OGD treatment; (E,F) LDH assay showed that overexpression of miR-378 substantially suppressed the cell death, while transfection of anti-miR-378 aggravated cell death induced by 3 h OGD/24 h reoxygenation, * p < 0.05 vs. normoxic non-trans, # p < 0.05 vs. OGD non-trans, n = 6 per group.