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Relationship between IAA affinity and the age of IAA appearance or HLA phenotype. (A) IAA affinity of the first IAA-positive sample in children who had the HLA DRB1*04/DQB1*0302 haplotype (HLA DR4) compared with those who did not have this haplotype (non–HLA DR4). (B) IAA affinity of the first IAA-positive sample in BABYDIAB children who developed IAAs at age 9 months or 2 years or at 5 years or older.
