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. 2004 Aug 16;114(4):589–597. doi: 10.1172/JCI21307

Figure 3.

Figure 3

Relationship between IAA affinity, multiple autoantibodies, and diabetes. (A) IAA affinity (l/mol) in the first IAA-positive sample from 56 children in the BABYDIAB study, in 16 IAA-positive relatives from the Munich family study, and in 11 insulin-treated patients with T1DM. Subjects in the BABYDIAB and Munich family studies are classified as having developed GAD antibodies, IA-2 antibodies, or cytoplasmic islet cell autoantibodies (multiple Ab’s) or not having developed these antibodies (IAAs only). (B) Relationship between IAA affinity (ordinate scale) and IAA titer (abscissa) for the 72 BABYDIAB and Munich family study sera. In A and B, subjects are identified as having developed multiple islet autoantibodies (circles), not having developed multiple islet autoantibodies (crosses), or having transient IAAs (triangles), and as having developed diabetes (filled symbols) or not (open symbols).