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Relationship between IAA affinity and relative binding to Tyr19A [125I] insulin. Percent binding to Tyr19A [125I] insulin relative to binding to Tyr14A [125I] insulin (abscissa) is shown in relation to IAA affinities (ordinate axis) for individual sera. Children who had or developed multiple islet autoantibodies are indicated by circles and those who did not develop multiple islet antibodies by crosses. Filled symbols represent children who developed diabetes.
