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. 2016 Aug 30;17(9):1431. doi: 10.3390/ijms17091431

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

lncRNA ZEB1-AS1 was a key regulator of glioma proliferation, apoptosis, migration, and invasion. (A) ZEB1-AS1 promoted the proliferation by significantly inducing the G0/G1 phase arrest and correspondingly decreasing the percentage of S phase in cell cycle; (B) ZEB1-AS1 inhibited the apoptosis of glioma cells; (C) ZEB1-AS1 activated EMT through up-regulating the expression of MMP2, MMP9, N-cadherin, and Integrin-β1 as well as decreasing E-cadherin levels and accelerating the migration and invasion of glioma cells.