Table 1.
The main reversible histone modifications.
| Enzyme | Target | Modification | References |
|---|---|---|---|
| Histone acetyltransferases (HATs), Histone deacetylases (HDACs) | Lysine | Acetylation Deacetylation | [30,31,32,33] |
| Lysine methyltransferases, arginine methyltransferases | Lysine Arginine | Methylation Demethylation | [34,35,36] |
| Kinases, phosphatase | Serine Threonine Tyrosine | Phosphorylation Dephosphorylation | [37] |
| Ubiquitin ligase (E3) and ubiquitin-activating enzyme (E1/E2), Small Ubiquitin-like Modifier (SUMO) | Lysine | Ubiquitylation Sumoylation Deubiquitylation | [38] |
| Poly (ADP-ribose) polymerase (PARP) | Glutamate Arginine | ADP-ribosylation | [38,39] |