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. 2016 Sep 8;17(9):1502. doi: 10.3390/ijms17091502

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Metabolism of thiopurine S-methyltransferases (TPMT). Metabolite: Azathioprine (AZA), Methylmercaptopurine (meMP), Methyl-thioguanosine monophosphate (meTGMP), Methyl-thioinosine monophosphate (mTIMP), Thioguanosine monophosphate (TGMP), Thioinosine monophosphate (TIMP), 6-mercaptopurine (6MP), 6-thioguanine (6TG). Enzyme: Glutathione-S-transferase A1, A2, M1 (GSTA1, GSTA2, GSTM1), Guanosine monophosphate synthetase (GMPS), Hypoxanthine guanine phosphoribosyl transferase (HPRT1), Inositol monophosphate dehydrogenase (IMPDH), Thiopurine methyltransferase (TPMT), Solute carrier family 8A2, 8A3, 29A1, 29A2 (SLC28A2, SLC28A3, SLC29A1, SLC29A2). Colors: blue—prodrug, drug or effect; green—inactive metabolites (adapted from [262]).