Table 1.
Body weight, organ parameters and serum PFOS concentrations in C57BL/6 mice exposed in utero to PFOS during Gestation Days (GD) 1–17.
| Sex | PFOS Gestational Exposure Level (mg/kg/day) | ||||
|---|---|---|---|---|---|
| 0.0 (Control) | 0.1 | 1.0 | 5.0 | ||
| 4 weeks of age | |||||
| Body weight (g) | Male | 16.13 ± 0.63 | 16.59 ± 0.75 | 14.70 ± 0.58 | 14.37 ± 0.62 |
| Female | 14.33 ± 0.37 | 14.16 ± 0.49 | 13.52 ± 0.31 | 13.28 ± 0.40 | |
| Spleen b | Male | 0.53 ± 0.04 | 0.49 ± 0.03 | 0.45 ± 0.05 | 0.42 ± 0.02 a |
| Female | 0.51 ± 0.03 | 0.48 ± 0.02 | 0.47 ± 0.04 | 0.45 ± 0.02 | |
| Thymus b | Male | 0.61 ± 0.05 | 0.54 ± 0.04 | 0.58 ± 0.03 | 0.49 ± 0.02 a |
| Female | 0.57 ± 0.03 | 0.59 ± 0.02 | 0.54 ± 0.02 | 0.51 ± 0.01 | |
| Kidney b | Male | 1.70 ± 0.05 | 1.74 ± 0.03 | 1.82 ± 0.04 | 1.76 ± 0.05 |
| Female | 1.67 ± 0.04 | 1.61 ± 0.05 | 1.74 ± 0.03 | 1.65 ± 0.04 | |
| Liver b | Male | 7.21 ± 0.14 | 6.97 ± 0.21 | 7.75 ± 0.17 | 8.16 ± 0.24 a |
| Female | 6.88 ± 0.15 | 6.65 ± 0.25 | 7.04 ± 0.22 | 7.59 ± 0.30 a | |
| Serum PFOS concentration (mg/L) | |||||
| Male | 0.05 ± 0.01 | 6.38 ± 0.35 | 47.03 ± 3.23 a | 118.40 ± 6.27 a | |
| Female | 0.04 ± 0.01 | 5.16 ± 0.27 | 41.81 ± 3.62 a | 107.53 ± 4.51 a | |
| 8 weeks of age | |||||
| Body weight (g) | Male | 23.04 ± 0.75 | 24.96 ± 0.64 | 25.12 ± 0.96 | 23.48 ± 0.43 |
| Female | 21.51 ± 0.91 | 22.84 ± 0.67 | 20.65 ± 0.59 | 19.37 ± 0.73 | |
| Spleen b | Male | 0.42 ± 0.03 | 0.37 ± 0.05 | 0.43 ± 0.02 | 0.32 ± 0.03 |
| Female | 0.45 ± 0.02 | 0.46 ± 0.03 | 0.41 ± 0.03 | 0.43 ± 0.04 | |
| Thymus b | Male | 0.30 ± 0.01 | 0.27 ± 0.02 | 0.29 ± 0.01 | 0.24 ± 0.03 a |
| Female | 0.33 ± 0.02 | 0.31 ± 0.03 | 0.36 ± 0.02 | 0.32 ± 0.01 | |
| Kidney b | Male | 1.59 ± 0.04 | 1.61 ± 0.03 | 1.68 ± 0.03 | 1.54 ± 0.06 |
| Female | 1.43 ± 0.11 | 1.57 ± 0.05 | 1.38 ± 0.04 | 1.46 ± 0.03 | |
| Liver b | Male | 6.60 ± 0.18 | 6.41 ± 0.14 | 7.05 ± 0.21 | 6.39 ± 0.17 |
| Female | 5.77 ± 0.21 | 5.94 ± 0.13 | 6.03 ± 0.07 | 5.82 ± 0.09 | |
| Serum PFOS concentration (mg/L) | |||||
| Male | 0.04 ± 0.01 | 3.79 ± 0.26 | 37.53 ± 3.96 a | 82.66 ± 4.18 a | |
| Female | 0.04 ± 0.01 | 3.04 ± 0.17 | 31.17 ± 2.59 a | 71.68 ± 4.49 a | |
Data reported as the mean ± SEM. a Value significantly different from sex/age control (p ≤ 0.05) by one-way ANOVA test. Body and organ mass data did not require transformation for statistical analysis. n = 12/group; b Calculated as: [organ weight (g)/body weight (g)] × 100.