Table 2.
Splenic lymphocyte sub-populations in C57BL6 mice exposed in utero to PFOS during GD 1–17.
| Sex | PFOS (mg/kg/day) | CD8+ (Cells × 106) | DP (Cells × 105) | CD4+ (Cells × 107) | B220 (Cells × 107) |
|---|---|---|---|---|---|
| 4 weeks of age | |||||
| Male | 0.0 (Control) | 10.62 ± 0.61 | 5.24 ± 0.94 | 2.21 ± 0.18 | 5.98 ± 0.41 |
| 0.1 | 10.86 ± 0.55 | 5.63 ± 0.37 | 2.06 ± 0.13 | 5.65 ± 0.35 | |
| 1.0 | 9.98 ± 0.43 | 6.76 ± 0.68 | 1.85 ± 0.25 | 5.14 ± 0.26 | |
| 5.0 | 8.49 ± 0.36 a | 6.48 ± 0.42 | 1.64 ± 0.09 a | 4.73 ± 0.21 a | |
| Female | 0.0 (Control) | 9.18 ± 0.67 | 4.51 ± 0.53 | 1.94 ± 0.33 | 5.44 ± 0.31 |
| 0.1 | 9.44 ± 0.58 | 5.76 ± 0.46 | 1.67 ± 0.32 | 5.62 ± 0.25 | |
| 1.0 | 8.59 ± 0.34 | 5.14 ± 0.70 | 1.74 ± 0.46 | 5.09 ± 0.19 | |
| 5.0 | 8.80 ± 0.75 | 4.28 ± 0.64 | 1.43 ± 0.27 | 4.47 ± 0.27 a | |
| 8 weeks of age | |||||
| Male | 0.0 | 5.69 ± 0.36 | 1.81 ± 0.60 | 1.77 ± 0.09 | 6.43 ± 0.25 |
| 0.1 | 6.07 ± 0.25 | 1.77 ± 0.28 | 1.54 ± 0.11 | 6.17 ± 0.28 | |
| 1.0 | 6.31 ± 0.30 | 2.14 ± 0.26 | 1.60 ± 0.08 | 5.90 ± 0.24 | |
| 5.0 | 5.78 ± 0.42 | 1.62 ± 0.19 | 1.37 ± 0.10 a | 5.74 ± 0.30 | |
| Female | 0.0 | 5.40 ± 0.34 | 1.69 ± 0.24 | 1.63 ± 0.14 | 4.41 ± 0.15 |
| 0.1 | 5.64 ± 0.45 | 1.78 ± 0.35 | 1.59 ± 0.13 | 4.64 ± 0.23 | |
| 1.0 | 6.01 ± 0.62 | 1.94 ± 0.58 | 1.46 ± 0.09 | 4.22 ± 0.19 | |
| 5.0 | 5.27 ± 0.33 | 1.61 ± 0.22 | 1.32 ± 0.07 | 3.17 ± 0.27 a |
Data are reported as the mean absolute number of cells ± SEM. DP = CD4+CD8+. n = 12 each group. a Value significantly different from respective sex/age control (p ≤ 0.05) by the one-way ANOVA test.