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. 2016 Sep 13;17(9):1535. doi: 10.3390/ijms17091535

Figure 4.

Figure 4

Plasma insulin levels and serum lipid profile. Blood samples were collected from the retro-orbital sinus of C57BL/6 mice with HFD + STZ-induced diabetic nephropathy. The plasma insulin levels were measured by ELISA at two, four, and eight weeks (A) and the plasma triglyceride (TG), total cholesterol (TC) and HDL/LDL ratio, respectively, were determined by the biochemistry analyzers at four and eight weeks. The modulation of plasma glucose and lipid metabolism were measured following LIOP (300 and 1000 mg/kg) and rosiglitazone (10 mg/kg) treatment as compared to the effects of the saline-alone group at four (B) and eight weeks (C). The data are expressed as mean ± SE of eight mice. *: p < 0.05, **: p < 0.01 as compared with the saline group at two, four, eight weeks. #: p < 0.05, ##: p < 0.01 compared with saline group at the two-week trial. Normal: native control; Saline: vehicle control; RS: rosiglitazone; LIOP: Low-molecular-weight, 10–100 kDa polysaccharides from Inonotus obliquus extract.