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. 2016 Sep 19;17(9):1560. doi: 10.3390/ijms17091560

Figure 3.

Figure 3

Influence of compounds 1a (A), 1b (B), 2a (C) and 2b (D) on conversion of relaxed plasmid DNA to supercoiled molecule. Control reactions were carried out in the absence of Topo I (supercoiled plasmid, SC) (lane 1), with Topo I (relaxed plasmid) (lane 2), with Topo I and 0.1% DMSO (lane 2A). Plasmid conformation was analyzed in increasing concentrations of investigated compounds (lane 3–9, concentration: 0.5; 1; 5; 10; 15; 20 and 30 µM, respectively) with constant Topo I concentration. 9AA (100 µM) was used as positive control (lane 10).