Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 19;17(9):1560. doi: 10.3390/ijms17091560

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Influence of 2a on Topo II activity. The Topo II-mediated plasmid cleavage assay was carried out over constant enzyme concentration. Lane 1: supercoiled plasmid, SC; lane 2: plasmid with Topo II after 15 min of incubation time; lane 3: plasmid with Topo II and etoposide (50 µM) after 15 min of incubation time (positive control); lane 4–8: plasmid with Topo II and in the presence of compound 2a at the concentration of 5, 10, 15, 20, 30 µM, respectively.