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Inflammasomes and the liver. In steatosis, hepatic damage leads to generation of damage-associated molecular pattern (DAMPs), while alterations in microbiota lead to increased availability of pathogen-associated molecular patterns (PAMPs). DAMPs and PAMPs act on receptors localized on liver cells leading to activation of different inflammasomes and release of cytokines implicated in NASH. NLRP3: NOD-like receptor family, pyrin domain containing 3; AIM2: Abscent in melanoma 2.
