Table 3.
Gene expression of the target genes when comparing the different canine mammary tissues from FFPE samples. Arrows show a higher or lower expression of the first group in relation to the second one (example: first group vs. second group).
| Target Gene | Lobular Hyperplasias vs. Malignant Tumors | Benign Tumors vs. Malignant Tumors |
|---|---|---|
| BRCA1 | - | - |
| BRCA2 | - | - |
| FOXO3 | ↑ ** | ↑ *** |
| GATA4 | - | - |
| HER2 | ↑ *** | ↑ *** |
| HMGA1 | ↑ * | - |
| HMGA2 | - | - |
| HMGB1 | ↑ *** | ↑ * |
| MAPK1 | - | - |
| MAPK3 | ↑ ** | ↑ *** |
| MCL1 | ↑ *** | ↑ *** |
| MYC | - | - |
| PFDN5 | ↑ ** | ↑ *** |
| PIK3CA | ↑ * | ↑ ** |
| PTEN | - | ↑ ** |
| TP53 | ↑ * | ↑ * |
Results are classified as significant (* p < 0.05), very significant (** p < 0.01), and extremely significant (*** p < 0.001). Cells with hyphen (-) revealed no significant differences.