Table 2.
Combinations of Antibody Classes | Multiple Sclerosis | Clinically Isolated Syndrome | ||
---|---|---|---|---|
Intrathecal Synthesis of Immunoglobulins | ||||
Reiber-Felgenhauer | Reiber-Felgenhauer + OCB | Reiber-Felgenhauer | Reiber-Felgenhauer + OCB | |
3-class synthesis of IgG + IgM + IgA | 7% | 8% | 3% | 3% |
2-class synthesis of IgG + IgM | 21% | 27% | 11% | 11% |
2-class synthesis of IgG + IgA | 4% | 5% | 1% | 1% |
2-class synthesis of IgM + IgA | 1% | 0 | 1% | 0 |
Isolated synthesis of IgG | 29% | 54% | 19% | 41% |
Isolated synthesis of IgM | 5% | 0 | 1% | 0 |
Isolated synthesis of IgA | 1% | 0 | 0 | 0 |
Presentation of different combinations of intrathecal synthesis of immunoglobulins IgG, IgM, and IgA; data show values assessed by the method of Reiber-Felgenhauer (quantitative method) and in combination with oligoclonal bands (OCB; qualitative method of intrathecal IgG synthesis).