Table 2.

Different combinations of intrathecal synthesis of immunoglobulins IgG, IgM, and IgA.

Combinations of Antibody Classes	Multiple Sclerosis		Clinically Isolated Syndrome
	Intrathecal Synthesis of Immunoglobulins
	Reiber-Felgenhauer	Reiber-Felgenhauer + OCB	Reiber-Felgenhauer	Reiber-Felgenhauer + OCB
3-class synthesis of IgG + IgM + IgA	7%	8%	3%	3%
2-class synthesis of IgG + IgM	21%	27%	11%	11%
2-class synthesis of IgG + IgA	4%	5%	1%	1%
2-class synthesis of IgM + IgA	1%	0	1%	0
Isolated synthesis of IgG	29%	54%	19%	41%
Isolated synthesis of IgM	5%	0	1%	0
Isolated synthesis of IgA	1%	0	0	0

Presentation of different combinations of intrathecal synthesis of immunoglobulins IgG, IgM, and IgA; data show values assessed by the method of Reiber-Felgenhauer (quantitative method) and in combination with oligoclonal bands (OCB; qualitative method of intrathecal IgG synthesis).